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GABA has also been investigated for use as a treatment for epilepsy. It appears that low levels of GABA in the brain have been linked to seizures in some cases. GABA seems to inhibit the firing of nerve cells that set off seizures. Since standard drugs for epilepsy enhance GABA levels in the brain, it is thought that supplements of GABA may be useful in preventing seizures, though clinical evidence is mixed so far. GABA is available in tablets, capsules and in powdered form. Capsules can be opened and mixed with liquid to make them easier to ingest. Sublingual tablets of GABA (tablets that are placed under the tongue to dissolve) are also available. The dosage of GABA to be used depends on the reason for taking it. To promote sleep, 500 to 1000 mg taken about and hour before bed is recommended. In cases where insomnia is related to anxiety, GABA can be taken with other natural tranquilizers, such as valerian root. The recommended dosage of GABA for treating chronic pain or to help prevent seizures is 250 to 500 mg taken three times per day. For stress, 250 mg three times per day or a single dose of 750 mg is usually effective. GABA is best absorbed and more effective when taken between meals. It should be stored away from heat and moisture in a cool, dry place. Because prescription medications for anxiety target GABA receptors in the brain, people who are taking such medications should not use GABA supplements without the advice of a medical professional. It is possible for GABA to produce significant drowsiness if it is taken with tranquilizers, including codeine and other narcotic pain relievers, so they should be taken together only with extreme caution. Though GABA is reportedly safe at recommended doses, some mild stomach irritation or nausea are possible. Some people also report drowsiness as a side effect. At high doses, GABA can exacerbate the very symptoms of anxiety and insomnia that it is supposed to alleviate, underscoring the need to use it within recommended amounts. Numbness around the mouth and tingling in the extremities are other possible side effects of high doses of GABA. Women who are pregnant or breast feeding and people with liver or kidney disease should not take GABA, since it has not been studied for safety among people in those groups.
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